Pharmacokinetics and Dose Recommendations for Cyclosporine and Tacrolimus When Coadministered With ABT‐450, Ombitasvir, and Dasabuvir

The authors describe the drug–drug interaction profile of the he patitis C direct‐acting antiviral agents ABT‐450, ombitasvir, and dasabuvir with cyclosporine A and tacrolimus, and use pha rmacokinetic simulations to develop recommendations for reduced doses of cyclosporine A and tacrolimus in postt...

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Enregistré dans:
Détails bibliographiques
Publié dans:Am J Transplant
Auteurs principaux: Badri, P., Dutta, S., Coakley, E., Cohen, D., Ding, B., Podsadecki, T., Bernstein, B., Awni, W., Menon, R.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024008/
https://ncbi.nlm.nih.gov/pubmed/25708713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.13111
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