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The effects of cytochrome P450 2C19 polymorphism on the metabolism of voriconazole in vitro
BACKGROUND: CYP/CYP450 2C19 (CYP2C19) is a highly polymorphic enzyme and exhibits individual differences in metabolic activity. The purpose of this research was mainly to explore the catalytic activities of 30 CYP2C19 variants on the substrate voriconazole in vitro, including 24 novel CYP2C19 varian...
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| Publicado no: | Infect Drug Resist |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6219421/ https://ncbi.nlm.nih.gov/pubmed/30464555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IDR.S179078 |
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