The effects of cytochrome P450 2C19 polymorphism on the metabolism of voriconazole in vitro

BACKGROUND: CYP/CYP450 2C19 (CYP2C19) is a highly polymorphic enzyme and exhibits individual differences in metabolic activity. The purpose of this research was mainly to explore the catalytic activities of 30 CYP2C19 variants on the substrate voriconazole in vitro, including 24 novel CYP2C19 varian...

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Bibliografiske detaljer
Udgivet i:Infect Drug Resist
Main Authors: Xu, Ren-ai, Gu, Er-min, Liu, Teng-hui, Ou-yang, Qiu-geng, Hu, Guo-xin, Cai, Jian-ping
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219421/
https://ncbi.nlm.nih.gov/pubmed/30464555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IDR.S179078
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