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Characterization of WY 14,643 and its Complex with Aldose Reductase

The peroxisome proliferator, WY 14,643 exhibits a pure non-competitive inhibition pattern in the aldehyde reduction and in alcohol oxidation activities of human Aldose reductase (hAR). Fluorescence emission measurements of the equilibrium dissociation constants, K(d), of oxidized (hAR•NADP(+)) and r...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Sawaya, Michael R., Verma, Malkhey, Balendiran, Vaishnavi, Rath, Nigam P., Cascio, Duilio, Balendiran, Ganesaratnam K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056380/
https://ncbi.nlm.nih.gov/pubmed/27721416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34394
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