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B-factor Analysis and Conformational Rearrangement of Aldose Reductase
The NADPH-dependent reduction of glucose reaction that is catalyzed by Aldose Reductase (AR) follows a sequential ordered kinetic mechanism in which the co-factor NADPH binds to the enzyme prior to the aldehyde substrate. The kinetic/structural experiments have found a conformational change involvin...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4212266/ https://ncbi.nlm.nih.gov/pubmed/25364319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/157016461103140922163444 |
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