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Factors affecting counteraction by methylamines of urea effects on aldose reductase

The concentration of urea in renal medullary cells is high enough to affect enzymes seriously by reducing V(max) or raising K(m), yet the cells survive and function. The usual explanation is that the methylamines found in the renal medulla, namely glycerophosphocholine and betaine, have actions oppo...

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Detalhes bibliográficos
Main Authors: Burg, Maurice B., Peters, Eugenia M., Bohren, Kurt M., Gabbay, Kenneth H.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC26914/
https://ncbi.nlm.nih.gov/pubmed/10339620
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