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Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers
AKR1B10 is an aldose reductase (AR) homologue overexpressed in liver cancer and various forms of that enzyme in carcinomas catalyze the reduction of anticancer drugs, potential cytostatic drug, and DL-glyceraldehyde but do not catalyze the reduction of glucose. Kinetic parameters for wild-type and C...
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| Publicado no: | Eur J Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6193476/ https://ncbi.nlm.nih.gov/pubmed/18325492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.01.036 |
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