The Role of Cys-298 in Aldose Reductase Function

Diabetic tissues are enriched in an “activated” form of human aldose reductase (hAR), a NADPH-dependent oxidoreductase involved in sugar metabolism. Activated hAR has reduced sensitivity to potential anti-diabetes drugs. The C298S mutant of hAR reproduces many characteristics of activated hAR, altho...

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Bibliographische Detailangaben
Hauptverfasser: Balendiran, Ganesaratnam K., Sawaya, Michael R., Schwarz, Frederick P., Ponniah, Gomathinayagam, Cuckovich, Richard, Verma, Malkhey, Cascio, Duilio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057803/
https://ncbi.nlm.nih.gov/pubmed/21084309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.154195
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