The novel late Na(+) current inhibitor, GS‐6615 (eleclazine) and its anti‐arrhythmic effects in rabbit isolated heart preparations

BACKGROUND AND PURPOSE: Enhanced late Na(+) current (late I(Na)) in the myocardium is pro‐arrhythmic. Inhibition of this current is a promising strategy to stabilize ventricular repolarization and suppress arrhythmias. Here, we describe GS‐6615, a selective inhibitor of late I(Na), already in clinic...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Rajamani, Sridharan, Liu, Gongxin, El‐Bizri, Nesrine, Guo, Donglin, Li, Cindy, Chen, Xiao‐Liang, Kahlig, Kristopher M, Mollova, Nevena, Elzein, Elfatih, Zablocki, Jeff, Belardinelli, Luiz
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056228/
https://ncbi.nlm.nih.gov/pubmed/27449698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13563
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