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The novel late Na(+) current inhibitor, GS‐6615 (eleclazine) and its anti‐arrhythmic effects in rabbit isolated heart preparations
BACKGROUND AND PURPOSE: Enhanced late Na(+) current (late I(Na)) in the myocardium is pro‐arrhythmic. Inhibition of this current is a promising strategy to stabilize ventricular repolarization and suppress arrhythmias. Here, we describe GS‐6615, a selective inhibitor of late I(Na), already in clinic...
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| Pubblicato in: | Br J Pharmacol |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5056228/ https://ncbi.nlm.nih.gov/pubmed/27449698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13563 |
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