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Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967

BACKGROUND: Previous studies have shown that late sodium channel current (I(Na)) blockers such as ranolazine can exert antiarrhythmic effects by suppressing early and delayed after-depolarization (EAD and DAD)-induced triggered activity. OBJECTIVE: To evaluate the electrophysiological properties of...

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Autori principali: Sicouri, Serge, Belardinelli, Luiz, Antzelevitch, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836836/
https://ncbi.nlm.nih.gov/pubmed/23524321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2013.03.023
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