Selective late sodium current inhibitor GS‐458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

BACKGROUND AND PURPOSE: Enhanced late sodium current (late I (Na)) in heart failure and long QT syndrome type 3 is proarrhythmic. This study investigated the antiarrhythmic effect and mode of action of the selective and potent late I (Na) inhibitor GS‐458967 (GS967) against Torsades de Pointes arrhy...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, Vos, Marc A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980463/
https://ncbi.nlm.nih.gov/pubmed/29582428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14217
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