Ranolazine selectively blocks persistent current evoked by epilepsy-associated Na(V)1.1 mutations

BACKGROUND AND PURPOSE: Mutations of SCN1A, the gene encoding the pore-forming subunit of the voltage-gated sodium channel Na(V)1.1, have been associated with a spectrum of genetic epilepsies and a familial form of migraine. Several mutant Na(V)1.1 channels exhibit increased persistent current due t...

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Detalhes bibliográficos
Main Authors: Kahlig, Kristopher M, Lepist, Irene, Leung, Kwan, Rajamani, Sridharan, George, Alfred L
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000664/
https://ncbi.nlm.nih.gov/pubmed/20735403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00976.x
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