Mechanisms by Which Ranolazine Terminates Paroxysmal but Not Persistent Atrial Fibrillation

BACKGROUND -: Ranolazine inhibits Na(+) current (I(Na)), but whether it can convert atrial fibrillation (AF) to sinus rhythm (SR) remains unclear. We investigated antiarrhythmic mechanisms of ranolazine in sheep models of paroxysmal (PxAF) and persistent AF (PsAF). METHODS -: PxAF was maintained dur...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Ramirez, Rafael J., Takemoto, Yoshio, Martins, Raphaël P., Filgueiras-Rama, David, Ennis, Steven R., Mironov, Sergey, Bhushal, Sandesh, Deo, Makarand, Rajamani, Sridharan, Berenfeld, Omer, Belardinelli, Luiz, Jalife, José, Pandit, Sandeep V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788778/
https://ncbi.nlm.nih.gov/pubmed/31594392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005557
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