Mechanisms by Which Ranolazine Terminates Paroxysmal but Not Persistent Atrial Fibrillation

BACKGROUND -: Ranolazine inhibits Na(+) current (I(Na)), but whether it can convert atrial fibrillation (AF) to sinus rhythm (SR) remains unclear. We investigated antiarrhythmic mechanisms of ranolazine in sheep models of paroxysmal (PxAF) and persistent AF (PsAF). METHODS -: PxAF was maintained dur...

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Vydáno v:Circ Arrhythm Electrophysiol
Hlavní autoři: Ramirez, Rafael J., Takemoto, Yoshio, Martins, Raphaël P., Filgueiras-Rama, David, Ennis, Steven R., Mironov, Sergey, Bhushal, Sandesh, Deo, Makarand, Rajamani, Sridharan, Berenfeld, Omer, Belardinelli, Luiz, Jalife, José, Pandit, Sandeep V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788778/
https://ncbi.nlm.nih.gov/pubmed/31594392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005557
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