Mechanisms by Which Ranolazine Terminates Paroxysmal but Not Persistent Atrial Fibrillation

BACKGROUND -: Ranolazine inhibits Na(+) current (I(Na)), but whether it can convert atrial fibrillation (AF) to sinus rhythm (SR) remains unclear. We investigated antiarrhythmic mechanisms of ranolazine in sheep models of paroxysmal (PxAF) and persistent AF (PsAF). METHODS -: PxAF was maintained dur...

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Published in:Circ Arrhythm Electrophysiol
Main Authors: Ramirez, Rafael J., Takemoto, Yoshio, Martins, Raphaël P., Filgueiras-Rama, David, Ennis, Steven R., Mironov, Sergey, Bhushal, Sandesh, Deo, Makarand, Rajamani, Sridharan, Berenfeld, Omer, Belardinelli, Luiz, Jalife, José, Pandit, Sandeep V.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788778/
https://ncbi.nlm.nih.gov/pubmed/31594392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005557
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