A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current

BACKGROUND: The QT interval is a phase of the cardiac cycle that corresponds to action potential duration (APD) including cellular repolarization (T-wave). In both clinical and experimental settings, prolongation of the QT interval of the electrocardiogram (ECG) and related proarrhythmia have been s...

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Udgivet i:J Mol Cell Cardiol
Main Authors: Yang, Pei-Chi, El-Bizri, Nesrine, Romero, Lucia, Giles, Wayne R., Rajamani, Sridharan, Belardinelli, Luiz, Clancy, Colleen E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453509/
https://ncbi.nlm.nih.gov/pubmed/27545042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.08.011
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