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In silico assessment of drug safety in human heart applied to late sodium current blockers
Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which may block different channels, remains an important opportunity. Partial block...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989354/ https://ncbi.nlm.nih.gov/pubmed/23696033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.24905 |
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