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In silico assessment of drug safety in human heart applied to late sodium current blockers

Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which may block different channels, remains an important opportunity. Partial block...

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Autors principals: Trenor, Beatriz, Gomis-Tena, Julio, Cardona, Karen, Romero, Lucia, Rajamani, Sridharan, Belardinelli, Luiz, Giles, Wayne R, Saiz, Javier
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989354/
https://ncbi.nlm.nih.gov/pubmed/23696033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.24905
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