Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact

Influenza virus strain-specific monoclonal antibodies (mAbs) provide protection independent of Fc gamma receptor (FcγR) engagement. In contrast, optimal in vivo protection achieved by broadly reactive mAbs requires Fc–FcγR engagement. Most strain-specific mAbs target the head domain of the viral hem...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Leon, Paul E., He, Wenqian, Mullarkey, Caitlin E., Bailey, Mark J., Miller, Matthew S., Krammer, Florian, Palese, Peter, Tan, Gene S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056099/
https://ncbi.nlm.nih.gov/pubmed/27647907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613225113
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