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Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact
Influenza virus strain-specific monoclonal antibodies (mAbs) provide protection independent of Fc gamma receptor (FcγR) engagement. In contrast, optimal in vivo protection achieved by broadly reactive mAbs requires Fc–FcγR engagement. Most strain-specific mAbs target the head domain of the viral hem...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5056099/ https://ncbi.nlm.nih.gov/pubmed/27647907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613225113 |
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