MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease caused by loss of motor neurons. ALS patients experience rapid deterioration in muscle function with an average lifespan of 3–5 years after diagnosis. Currently, the most effective therapeutic only extends lifespan by a few months, t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Glajch, Kelly E., Ferraiuolo, Laura, Mueller, Kaly A., Stopford, Matthew J., Prabhkar, Varsha, Gravanis, Achille, Shaw, Pamela J., Sadri-Vakili, Ghazaleh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055348/
https://ncbi.nlm.nih.gov/pubmed/27716798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164103
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