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Synthesis and evaluation of phenylalanine-derived trifluoromethyl ketones for peptide-based oxidation catalysis

We report the synthesis of phenylalanine-derived trifluoromethyl ketones for the in situ generation of dioxiranes for the purpose of oxidation catalysis. The key features of this synthesis include the use of a masked ketone strategy and a Negishi cross -coupling to access the parent amino acid. The...

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Publicado no:Bioorg Med Chem
Main Authors: Featherston, Aaron L., Miller, Scott J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053897/
https://ncbi.nlm.nih.gov/pubmed/27452284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.07.012
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