Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease

A series of trifluoromethyl ketones as SARS-CoV 3CL protease inhibitors was developed. The inhibitors were synthesized in four steps from commercially available compounds. Three different amino acids were explored in the P1-position and in the P2–P4 positions varying amino acids and long alkyl chain...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Shao, Yi-Ming, Yang, Wen-Bin, Kuo, Tun-Hsun, Tsai, Keng-Chang, Lin, Chun-Hung, Yang, An-Suei, Liang, Po-Huang, Wong, Chi-Huey
Format: Artigo
Sprache:Inglês
Veröffentlicht: Published by Elsevier Ltd. 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127754/
https://ncbi.nlm.nih.gov/pubmed/18329272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.02.040
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