Structure‐Based Design and Synthesis of Highly Potent SARS‐CoV 3CL Protease Inhibitors

In a successful example of lead optimization by computer modeling prediction, computational technology was used to optimize a lead inhibitor (TL‐3) of the SARS‐CoV 3CL protease. A novel C (2)‐symmetric diol (1) was then designed and synthesized, and displayed higher affinity than the original lead c...

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Gardado en:
Detalles Bibliográficos
Publicado en:Chembiochem
Main Authors: Shao, Yi‐Ming, Yang, Wen‐Bin, Peng, Hung‐Pin, Hsu, Min‐Feng, Tsai, Keng‐Chang, Kuo, Tun‐Hsun, Wang, Andrew H.‐J., Liang, Po‐Huang, Lin, Chun‐Hung, Yang, An‐Suei, Wong, Chi‐Huey
Formato: Artigo
Idioma:Inglês
Publicado: WILEY‐VCH Verlag 2007
Assuntos:
Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162026/
https://ncbi.nlm.nih.gov/pubmed/17722121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200700254
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