Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters

The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation. A series of tripeptide α,β-unsaturated esters and ketomethylene isosteres, including AG7088, are synthesized and assayed to target the 3CL protease....

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Bioorg Med Chem
Hlavní autoři: Shie, Jiun-Jie, Fang, Jim-Min, Kuo, Tun-Hsun, Kuo, Chih-Jung, Liang, Po-Huang, Huang, Hung-Jyun, Wu, Yin-Ta, Jan, Jia-Tsrong, Cheng, Yih-Shyun E., Wong, Chi-Huey
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Ltd. 2005
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7119063/
https://ncbi.nlm.nih.gov/pubmed/15994085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2005.05.065
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky