Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters

The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation. A series of tripeptide α,β-unsaturated esters and ketomethylene isosteres, including AG7088, are synthesized and assayed to target the 3CL protease....

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Publicat a:Bioorg Med Chem
Autors principals: Shie, Jiun-Jie, Fang, Jim-Min, Kuo, Tun-Hsun, Kuo, Chih-Jung, Liang, Po-Huang, Huang, Hung-Jyun, Wu, Yin-Ta, Jan, Jia-Tsrong, Cheng, Yih-Shyun E., Wong, Chi-Huey
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Ltd. 2005
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7119063/
https://ncbi.nlm.nih.gov/pubmed/15994085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2005.05.065
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