Structural basis of mercury‐ and zinc‐conjugated complexes as SARS‐CoV 3C‐like protease inhibitors

Five active metal‐conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C‐like protease of severe acute respiratory syndrome (SARS)‐associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)‐PMA is coordinated to...

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Detalles Bibliográficos
Publicado en:FEBS Lett
Main Authors: Lee, Cheng-Chung, Kuo, Chih-Jung, Hsu, Min-Feng, Liang, Po-Huang, Fang, Jim-Min, Shie, Jiun-Jie, Wang, Andrew H.-J.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2007
Assuntos:
Short Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7094272/
https://ncbi.nlm.nih.gov/pubmed/17981158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.10.048
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