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Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system
A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the potent greenhouse gas fluoroform (HCF(3), HFC-23) was developed. The combination of fluoroform and KHMDS in triglyme at −40 °C was effective for this...
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| Published in: | Beilstein J Org Chem |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Beilstein-Institut
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7884878/ https://ncbi.nlm.nih.gov/pubmed/33633811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.17.39 |
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