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Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system

A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the potent greenhouse gas fluoroform (HCF(3), HFC-23) was developed. The combination of fluoroform and KHMDS in triglyme at −40 °C was effective for this...

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Dades bibliogràfiques
Publicat a:Beilstein J Org Chem
Autors principals: Fujihira, Yamato, Liang, Yumeng, Ono, Makoto, Hirano, Kazuki, Kagawa, Takumi, Shibata, Norio
Format: Artigo
Idioma:Inglês
Publicat: Beilstein-Institut 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884878/
https://ncbi.nlm.nih.gov/pubmed/33633811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.17.39
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