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Direct nucleophilic trifluoromethylation of carbonyl compounds by potent greenhouse gas, fluoroform: Improving the reactivity of anionoid trifluoromethyl species in glymes

A simple protocol to overcome the problematic trifluoromethylation of carbonyl compounds by the potent greenhouse gas “HFC-23, fluoroform” with a potassium base is described. Simply the use of glymes as a solvent or an additive dramatically improves the yields of this transformation. Experimental re...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Saito, Takuya, Wang, Jiandong, Tokunaga, Etsuko, Tsuzuki, Seiji, Shibata, Norio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068191/
https://ncbi.nlm.nih.gov/pubmed/30065282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29748-1
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