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Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats
Tetrahydrobiopterin (BH(4)) is an essential cofactor of nitric oxide synthase (NOS) and aromatic amino acid hydroxylases. BH(4) and 7,8-dihydrobiopterin (BH(2)) are metabolically interchangeable at the expense of NADPH. Exogenously administered BH(4) can be metabolized by the body, similar to vitami...
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| Publicat a: | PLoS One |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5053593/ https://ncbi.nlm.nih.gov/pubmed/27711248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164305 |
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