Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats

Tetrahydrobiopterin (BH(4)) is an essential cofactor of nitric oxide synthase (NOS) and aromatic amino acid hydroxylases. BH(4) and 7,8-dihydrobiopterin (BH(2)) are metabolically interchangeable at the expense of NADPH. Exogenously administered BH(4) can be metabolized by the body, similar to vitami...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ohashi, Akiko, Saeki, Yusuke, Harada, Tomonori, Naito, Masako, Takahashi, Tomihisa, Aizawa, Shin, Hasegawa, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053593/
https://ncbi.nlm.nih.gov/pubmed/27711248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164305
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