The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion

Reduced nitric oxide (NO) bioavailability and increased oxidative stress are major factors mediating ischemia/reperfusion (I/R) injury. Tetrahydrobiopterin (BH(4)) is an essential cofactor of endothelial NO synthase (eNOS) to produce NO, whereas dihydrobiopterin (BH(2)) can shift the eNOS product pr...

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Autori principali: Chen, Qian, Kim, Elizabeth Eun Jung, Elio, Katrina, Zambrano, Christopher, Krass, Samuel, Teng, Jane Chun-wen, Kay, Helen, Perkins, Kerry-Anne, Pershad, Sailesh, McGraw, Sloane, Emrich, Jeffrey, Adams, Jovan S., Young, Lindon H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005837/
https://ncbi.nlm.nih.gov/pubmed/21188246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/963914
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