Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats

Tetrahydrobiopterin (BH(4)) is an essential cofactor of nitric oxide synthase (NOS) and aromatic amino acid hydroxylases. BH(4) and 7,8-dihydrobiopterin (BH(2)) are metabolically interchangeable at the expense of NADPH. Exogenously administered BH(4) can be metabolized by the body, similar to vitami...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Ohashi, Akiko, Saeki, Yusuke, Harada, Tomonori, Naito, Masako, Takahashi, Tomihisa, Aizawa, Shin, Hasegawa, Hiroyuki
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053593/
https://ncbi.nlm.nih.gov/pubmed/27711248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164305
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