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Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit

The design, synthesis, and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) derivatives are detailed representing analogs of duocarmycin SA and yatakemycin containing an imidazole replacement for the fused pyrrole found in the DNA alkylation subun...

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Bibliografiska uppgifter
I publikationen:Bioorg Med Chem
Huvudupphovsmän: Chanda, Prem B., Boyle, Kristopher E., Brody, Daniel M., Shukla, Vyom, Boger, Dale L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052114/
https://ncbi.nlm.nih.gov/pubmed/27221071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.04.050
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