CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents.
Key studies defining the DNA alkylation properties and selectivity of a new class of exceptionally potent, naturally occurring antitumor antibiotics including CC-1065, duocarmycin A, and duocarmycin SA are reviewed. Recent studies conducted with synthetic agents containing deep-seated structural cha...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42018/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731958/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3642 |
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