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Synthesis and Characterization of a Cyclobutane Duocarmycin Derivative Incorporating the CbBI (1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4-one) Alkylation Subunit
The synthesis of 1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4- one (17, CbBI), containing a deep-seated fundamental structural modification in the CC-1065 and duocarmycin alkylation subunit with the incorporation of a ring expanded fused cyclobutane (vs cyclopropane), its chemical and structu...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952436/ https://ncbi.nlm.nih.gov/pubmed/20839806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja106986f |
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