Synthesis and Preliminary Evaluation of Duocarmycin Analogues Incorporating the 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[2,3-e]indol-4-one (CNI) and 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[1,2-e]indol-4-one (iso-CNI) Alkylation Subunits

Efficient syntheses and a preliminary evaluation of 1,2,11,11a-tetrahydrocyclopropa[c]-naphtho[2,3-e]indole (CNI) and 1,2,11,11a-tetrahydrocyclopropa[c]naphtho[1,2-e]indole (iso-CNI), and their derivatives containing an anthracene and phenanthrene variant of the CC-1065 or duocarmycin alkylation sub...

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Main Authors: Gauss, Carla M., Hamasaki, Akiyuki, Parrish, Jay P., MacMillan, Karen S., Rayl, Thomas J., Hwang, Inkyu, Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713043/
https://ncbi.nlm.nih.gov/pubmed/20161204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2009.02.065
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