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Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.

The segregation of mutant and wild-type mtDNA was investigated in transformants constructed by transferring human mitochondria from individuals belonging to four pedigrees with the MELAS encephalomyopathy-associated mtDNA mutation (MELAS is mitochondrial myopathy, encephalopathy, lactic acidosis, an...

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Detalles Bibliográficos
Main Authors: Yoneda, M, Chomyn, A, Martinuzzi, A, Hurko, O, Attardi, G
Formato: Artigo
Idioma:Inglês
Publicado: 1992
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC50510/
https://ncbi.nlm.nih.gov/pubmed/1454794
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