MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

The pathogenetic mechanism of the mitochondrial tRNA(LeuUUR) gene mutation responsible for the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome was investigated in transformants obtained by transfer of mitochondria from three genetically unrelated ME...

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Detalhes bibliográficos
Main Authors: Chomyn, A, Martinuzzi, A, Yoneda, M, Daga, A, Hurko, O, Johns, D, Lai, S T, Nonaka, I, Angelini, C, Attardi, G
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC49053/
https://ncbi.nlm.nih.gov/pubmed/1584755
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