MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

The pathogenetic mechanism of the mitochondrial tRNA(LeuUUR) gene mutation responsible for the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome was investigated in transformants obtained by transfer of mitochondria from three genetically unrelated ME...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Chomyn, A, Martinuzzi, A, Yoneda, M, Daga, A, Hurko, O, Johns, D, Lai, S T, Nonaka, I, Angelini, C, Attardi, G
פורמט: Artigo
שפה:Inglês
יצא לאור: 1992
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC49053/
https://ncbi.nlm.nih.gov/pubmed/1584755
תגים: הוספת תג
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