Efficient tumor regression by adoptively transferred CEA-specific CAR-T cells associated with symptoms of mild cytokine release syndrome

Carcinoembryonic antigen (CEA) is a cell surface antigen highly expressed in various cancer cell types and in healthy tissues. It has the potential to be a target for chimeric antigen receptor (CAR)-modified T-cell therapy; however, the safety of this approach in terms of on-target/off-tumor effects...

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Publicat a:Oncoimmunology
Autors principals: Wang, Linan, Ma, Ning, Okamoto, Sachiko, Amaishi, Yasunori, Sato, Eiichi, Seo, Naohiro, Mineno, Junichi, Takesako, Kazutoh, Kato, Takuma, Shiku, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048773/
https://ncbi.nlm.nih.gov/pubmed/27757303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1211218
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