A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy

Aurora Kinase A is a cancer-associated protein normally involved in the regulation of mitosis. Being over-expressed in a range of cancers, it is a suitable target for cell-based immunotherapy. Gene transfer of T-cell receptor sequences cognisant of HLA-A*0201-restricted Aurora Kinase A antigen has p...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Casey, Nicholas Paul, Fujiwara, Hiroshi, Tanimoto, Kazushi, Okamoto, Sachiko, Mineno, Junichi, Kuzushima, Kiyotaka, Shiku, Hiroshi, Yasukawa, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896450/
https://ncbi.nlm.nih.gov/pubmed/27271876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156896
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