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E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis
The multifunctional protein E4 transcription factor 1 (E4F1) is an essential regulator of epidermal stem cell (ESC) maintenance. Here, we found that E4F1 transcriptionally regulates a metabolic program involved in pyruvate metabolism that is required to maintain skin homeostasis. E4F1 deficiency in...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | Proc Natl Acad Sci U S A |
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Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
National Academy of Sciences
2016
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5047149/ https://ncbi.nlm.nih.gov/pubmed/27621431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602751113 |
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