E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity

The mitochondrial pyruvate dehydrogenase (PDH) complex (PDC) acts as a central metabolic node that mediates pyruvate oxidation and fuels the tricarboxylic acid cycle to meet energy demand. Here, we reveal another level of regulation of the pyruvate oxidation pathway in mammals implicating the E4 tra...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Lacroix, Matthieu, Rodier, Geneviève, Kirsh, Olivier, Houles, Thibault, Delpech, Hélène, Seyran, Berfin, Gayte, Laurie, Casas, Francois, Pessemesse, Laurence, Heuillet, Maud, Bellvert, Floriant, Portais, Jean-Charles, Berthet, Charlene, Bernex, Florence, Brivet, Michele, Boutron, Audrey, Le Cam, Laurent, Sardet, Claude
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047171/
https://ncbi.nlm.nih.gov/pubmed/27621446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602754113
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