E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis

The multifunctional protein E4 transcription factor 1 (E4F1) is an essential regulator of epidermal stem cell (ESC) maintenance. Here, we found that E4F1 transcriptionally regulates a metabolic program involved in pyruvate metabolism that is required to maintain skin homeostasis. E4F1 deficiency in...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Goguet-Rubio, Perrine, Seyran, Berfin, Gayte, Laurie, Bernex, Florence, Sutter, Anne, Delpech, Hélène, Linares, Laetitia Karine, Riscal, Romain, Repond, Cendrine, Rodier, Geneviève, Kirsh, Olivier, Touhami, Jawida, Noel, Jean, Vincent, Charles, Pirot, Nelly, Pavlovic, Guillaume, Herault, Yann, Sitbon, Marc, Pellerin, Luc, Sardet, Claude, Lacroix, Matthieu, Le Cam, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047149/
https://ncbi.nlm.nih.gov/pubmed/27621431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602751113
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