Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer

BACKGROUND: There is increasing evidence that oncogenic Wnt signaling directs metabolic reprogramming of cancer cells to favor aerobic glycolysis or Warburg metabolism. In colon cancer, this reprogramming is due to direct regulation of pyruvate dehydrogenase kinase 1 (PDK1) gene transcription. Addit...

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Detaylı Bibliyografya
Yayımlandı:Cancer Metab
Asıl Yazarlar: Sprowl-Tanio, Stephanie, Habowski, Amber N., Pate, Kira T., McQuade, Miriam M., Wang, Kehui, Edwards, Robert A., Grun, Felix, Lyou, Yung, Waterman, Marian L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2016
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5046889/
https://ncbi.nlm.nih.gov/pubmed/27729975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-016-0159-3
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