Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner

Cellular pyruvate is an essential metabolite at the crossroads of glycolysis and oxidative phosphorylation, capable of supporting fermentative glycolysis by reduction to lactate mediated by lactate dehydrogenase (LDH) among other functions. Several inherited diseases of mitochondrial metabolism impa...

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Vydáno v:J Biol Chem
Hlavní autoři: Rao, Yi, Gammon, Seth T., Sutton, Margie N., Zacharias, Niki M., Bhattacharya, Pratip, Piwnica-Worms, David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233206/
https://ncbi.nlm.nih.gov/pubmed/34022218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100775
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