Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer

BACKGROUND: There is increasing evidence that oncogenic Wnt signaling directs metabolic reprogramming of cancer cells to favor aerobic glycolysis or Warburg metabolism. In colon cancer, this reprogramming is due to direct regulation of pyruvate dehydrogenase kinase 1 (PDK1) gene transcription. Addit...

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Bibliografiske detaljer
Udgivet i:Cancer Metab
Main Authors: Sprowl-Tanio, Stephanie, Habowski, Amber N., Pate, Kira T., McQuade, Miriam M., Wang, Kehui, Edwards, Robert A., Grun, Felix, Lyou, Yung, Waterman, Marian L.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5046889/
https://ncbi.nlm.nih.gov/pubmed/27729975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-016-0159-3
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