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Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy

The highly conserved Wnt signalling pathway plays an important role in embryonic development and disease pathogenesis, most notably cancer. The ‘canonical’ or β‐catenin‐dependent Wnt signal initiates at the cell plasma membrane with the binding of Wnt proteins to Frizzled:LRP5/LRP6 receptor complexe...

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Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Lyou, Yung, Habowski, Amber N, Chen, George T, Waterman, Marian L
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727325/
https://ncbi.nlm.nih.gov/pubmed/28752891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13963
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