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Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy

The highly conserved Wnt signalling pathway plays an important role in embryonic development and disease pathogenesis, most notably cancer. The ‘canonical’ or β‐catenin‐dependent Wnt signal initiates at the cell plasma membrane with the binding of Wnt proteins to Frizzled:LRP5/LRP6 receptor complexe...

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Foilsithe in:Br J Pharmacol
Main Authors: Lyou, Yung, Habowski, Amber N, Chen, George T, Waterman, Marian L
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727325/
https://ncbi.nlm.nih.gov/pubmed/28752891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13963
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