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Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy
The highly conserved Wnt signalling pathway plays an important role in embryonic development and disease pathogenesis, most notably cancer. The ‘canonical’ or β‐catenin‐dependent Wnt signal initiates at the cell plasma membrane with the binding of Wnt proteins to Frizzled:LRP5/LRP6 receptor complexe...
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| 出版年: | Br J Pharmacol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727325/ https://ncbi.nlm.nih.gov/pubmed/28752891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13963 |
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