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Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy
The highly conserved Wnt signalling pathway plays an important role in embryonic development and disease pathogenesis, most notably cancer. The ‘canonical’ or β‐catenin‐dependent Wnt signal initiates at the cell plasma membrane with the binding of Wnt proteins to Frizzled:LRP5/LRP6 receptor complexe...
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| Publicado no: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727325/ https://ncbi.nlm.nih.gov/pubmed/28752891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13963 |
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