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Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy
The highly conserved Wnt signalling pathway plays an important role in embryonic development and disease pathogenesis, most notably cancer. The ‘canonical’ or β‐catenin‐dependent Wnt signal initiates at the cell plasma membrane with the binding of Wnt proteins to Frizzled:LRP5/LRP6 receptor complexe...
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| Publié dans: | Br J Pharmacol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727325/ https://ncbi.nlm.nih.gov/pubmed/28752891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13963 |
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