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The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature

Given prostate cancer is driven, in part, by its responsiveness to androgens, treatments historically employ methods for their removal from circulation. Approaches as crude as castration, and more recently blockade of androgen synthesis or receptor binding, are still of limited use long term, since...

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Pubblicato in:J Steroid Biochem Mol Biol
Autori principali: Bird, Ian M, Abbott, David H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5046225/
https://ncbi.nlm.nih.gov/pubmed/27154414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2016.04.021
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