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Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b(5) in Leydig Cells
Androgen and estrogen biosynthesis in mammals requires the 17,20-lyase activity of cytochrome P450 17A1 (steroid 17-hydroxylase/17,20-lyase). Maximal 17,20-lyase activity in vitro requires the presence of cytochrome b(5) (b5), and rare cases of b5 deficiency in human beings causes isolated 17,20-lya...
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| Udgivet i: | Mol Endocrinol |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Endocrine Society
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4814474/ https://ncbi.nlm.nih.gov/pubmed/26974035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1282 |
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