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Antibody humanization by structure-based computational protein design
Antibodies derived from non-human sources must be modified for therapeutic use so as to mitigate undesirable immune responses. While complementarity-determining region (CDR) grafting-based humanization techniques have been successfully applied in many cases, it remains challenging to maintain the de...
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| Udgivet i: | MAbs |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5045135/ https://ncbi.nlm.nih.gov/pubmed/26252731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1076600 |
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