Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy

Neurodegenerative disorders referred to as tauopathies, which includes Alzheimer’s disease (AD), are characterized by insoluble deposits of the tau protein within neuron cell bodies and dendritic processes in the brain. Tau is normally associated with microtubules (MTs) in axons, where it provides M...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: Makani, Vishruti, Zhang, Bin, Han, Heeoon, Yao, Yuemang, Lassalas, Pierrik, Lou, Kevin, Paterson, Ian, Lee, Virginia M. Y., Trojanowski, John Q., Ballatore, Carlo, Smith, Amos B., Brunden, Kurt R.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043530/
https://ncbi.nlm.nih.gov/pubmed/27687527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0378-4
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