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DNA shape features improve transcription factor binding site predictions in vivo

Interactions of transcription factors (TFs) with DNA comprise a complex interplay between base-specific amino acid contacts and readout of DNA structure. Recent studies highlighted the complementarity of DNA sequence and shape in modeling TF binding in vitro. Here, we provide a comprehensive evaluat...

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Publicat a:Cell Syst
Autors principals: Mathelier, Anthony, Xin, Beibei, Chiu, Tsu-Pei, Yang, Lin, Rohs, Remo, Wasserman, Wyeth W.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042832/
https://ncbi.nlm.nih.gov/pubmed/27546793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.07.001
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