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DNA shape features improve transcription factor binding site predictions in vivo

Interactions of transcription factors (TFs) with DNA comprise a complex interplay between base-specific amino acid contacts and readout of DNA structure. Recent studies highlighted the complementarity of DNA sequence and shape in modeling TF binding in vitro. Here, we provide a comprehensive evaluat...

詳細記述

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書誌詳細
出版年:Cell Syst
主要な著者: Mathelier, Anthony, Xin, Beibei, Chiu, Tsu-Pei, Yang, Lin, Rohs, Remo, Wasserman, Wyeth W.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042832/
https://ncbi.nlm.nih.gov/pubmed/27546793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.07.001
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